Too Much Protein, Fat, May Lead to Insulin Resistance
A clue about the blood chemistry of obese people who develop insulin resistance, a precursor to diabetes, has been confirmed in animal studies at the Duke University Medical Center.
Obese people have been found to harbor proteins called branched-chain amino acids (BCAAs) at far higher levels than non-obese people. The suspicion has been that these amino acids, in combination with a high-fat diet, contribute to insulin resistance. The team found that the BCAA signature in obese humans consisted of the branched-chain amino acids themselves, plus a cluster of several products related to the bodys breakdown processes for BCAA.
In the case of the amino acids, we also are finding increased levels of their metabolic breakdown products, which suggests the whole system for handling the amino acid metabolic process has been overloaded, said senior author Christopher Newgard, Ph.D., director of the Sarah W. Stedman Nutrition and Metabolism Center and W. David and Sarah W. Stedman Distinguished Professor at Duke. Our rat studies show that this overload causes changes at the cellular level that can lead to insulin resistance.
To determine whether the BCAA signature in obese humans might signal that their intake is harmful, the scientists performed a feeding study in rats that showed an independent contribution of BCAAs to insulin resistance.
These findings, however, would need to be confirmed in studies with people before any dietary recommendations could be issued, said Laura Svetkey, M.D., director of the Duke Hypertension Center, director of clinical research at the Sarah W. Stedman Nutrition and Metabolism Center, and co-senior author of the study, published in Cell Metabolism.
“Insulin resistance occurred in animals with a diet high in the branched-chain amino acids, but only if they were ingested along with a high level of fat in the diet, Newgard said. Because obese humans tend to ingest high-fat diets, the combination of high-BCAA and high-fat intake might contribute to insulin resistance in obese humans, but additional studies are needed. BCAAs constitute as much as 25 percent of amino acids in dietary protein, and are particularly enriched in diets high in animal (meat) proteins.
Duration : 0:2:31
September 14th, 2009 at 2:58 pm
Reducing fat and …
Reducing fat and protein in the patient’s diet, works as a very effective treatment for insulin resistance. A whole, plant-based approach can render some forms of type 2 diabetes into remission. I am very happy to see researchers explaining the mechanism behind this treatment strategy.
September 14th, 2009 at 2:58 pm
i know that they …
i know that they get away, but in the moment of maximum pain, it was almost impossible to think clear or not to think about carbohydrates.anyways.. have a good week.
September 14th, 2009 at 2:58 pm
The first four days …
The first four days are the hardest but I was determined to complete a full body tranformation. It gets easier after about 1 week and yes, I did get headaches but that goes away too. It depends on how much you want to achieve ur goal I guess.
September 14th, 2009 at 2:58 pm
it works fast …
it works fast because if there isn´t any carbs at all, than our metabolism switched to fatburningmode!
i tried it more tha 2 years ago, but gave up after 4 days because of unbelievable strong headaches.probably migrane attack at it´s best.24 hours later and after adding regular amount of carbs everything went fine.
yeah, if we want to lift weights in the gym, 30gramm of carbs is just not enough to get stronger!there we really need some more of this fatal stuff!
September 14th, 2009 at 2:58 pm
Yes indeed. I’ve …
Yes indeed. I’ve just proved that actually.I spent 14 weeks on a low carb <30g a day coupled with 30-40min cardio and resistance training per day to lose fat. It work fast! However I always felt hungry although I was eating a massive amounts of protein and salad/ veg with good fats and couldn’t think straight. When I got my body fat under control I added carbs to my diet and immedietly became stonger in the gym and regained 100% brain function.Low carb solved my weight problem but we NEED carbs
September 14th, 2009 at 2:58 pm
without the part of …
without the part of the short lived seasonal fruit thing, i would´ve given you a thumbs down!
and this because for what i have learned, the human brain needs a minimum of 70gramms or carbohydrates/day!
September 14th, 2009 at 2:58 pm
Dukemedicine you …
Dukemedicine you have two people that disagree with this video would you please consider takeing it down. If you give me a vaild argument then that I will maybe change my views.
September 14th, 2009 at 2:58 pm
Your right.. in …
Your right.. in nature it would have been a bonus to get carbs as our bodies run more efficiently but we are genetically designed to eat protein and fat with the short lived seasonal fruits.
September 14th, 2009 at 2:58 pm
What is this …
What is this garbage, our ancients ate the fat from the fat for thousands of years and didnt have all these dieases we have. Carbs are not needed to live